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00 What are mesenchymal stem cells (MSC)

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댓글 0건 조회 1,531회 작성일 24-04-16 11:15

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Mesenchymal stem cells (MSC) are a type of adult stem cell and refer to stem cells that exist in umbilical cord blood, Wharton's jelly, adipose tissue, and bone marrow, etc., differentiated from the mesoderm produced by division of a fertilized egg.

characteristic:
Multipotency: MSCs have the ability to differentiate into various cells, including cartilage, hair, muscle, blood vessels, and nerve cells, under certain conditions.
Proliferative ability: MSCs have a higher proliferative ability than other stem cells, making them easy to mass produce.
Immunomodulatory function: MSCs have the ability to regulate immune responses and reduce rejection in tissue transplants, so they can be used for immunomodulating.
How to obtain: MSCs can be collected from bone marrow, umbilical cord blood, adipose tissue, Wharton's jelly, etc.

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Areas of use:
Tissue regeneration: MSCs are transplanted to regenerate damaged tissue. (e.g. blood vessel regeneration, cartilage regeneration, myocardial regeneration)
Cell therapy: MSCs are used to treat various diseases such as degenerative diseases, autoimmune diseases, anti-aging, immune diseases, and cardiovascular diseases. (e.g. degenerative arthritis, lupus, Crohn's disease)
Tissue engineering: MSCs are used to create artificial organs or tissues.

3-1. Why is there so much interest in mesenchymal stem cells (MSCs)?

Stem cells can be derived into specific cells that can be used to regenerate and repair tissues damaged or affected by disease.

People who may benefit from stem cell therapy include those with spinal cord injury, type 1 diabetes, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, heart disease, stroke, burns and osteoarthritis.

Stem cells have the potential to grow into new tissues for use in transplantation and regenerative medicine.
Researchers are actively advancing knowledge of stem cells and their applications in transplantation and regenerative medicine.

3-2. Is mesenchymal stem cell (MSC) treatment safe?

current situation

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Highly safe cell therapy: MSC is a cell therapy that cannot differentiate into cancer if the culture conditions are set accurately and cultured through thorough aseptic manipulation.

future prospects

Expansion of clinical trials: In the future, it is expected that more clinical trials will prove the safety and efficacy of MSCs and that they will be used to develop treatments for various diseases.

3-3. Is it possible for the body to reject mesenchymal stem cells (MSCs)?
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MSC is a cell therapy with high safety as it rarely causes immune rejection.
However, MSCs cultured for long periods of time, contaminated cells, and the patient's specific immune status may cause rejection.
Therefore, strict quality control and careful monitoring of the patient's condition are required to ensure safe treatment.

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